摘要
目的:优选广佛手配方颗粒除杂工艺。方法:比较乙醇沉淀法、高速离心法的浸膏得率和5,7-二甲氧基香豆素的保留率,并采用药效试验对除杂效果进行考察。结果:乙醇沉淀法除杂效果明显,有效成分保留率较高;高速离心法除杂效果差,有效成分保留率高;药效试验研究结果表明,两种除杂方法所得药液在药效作用上差异无统计学意义。结论:50%的乙醇沉淀法可作为广佛手配方颗粒除杂工艺。
Objective： To screen and optimize the removing impurity process of fructus citri sarcodacty]is formula-granules. Meth- od ： The extracta yield and remaining ratio of 5,7-Dimethoxycoumarin were used as investigation index, the purification conditions of al- cohol-precipitation and high speed centrffngation were compared, and pharmaeodynamie experiment was used to evaluate the purification effect. Result： The effect of purification by alcohol-precipitation was significant,the remaining ratio of active ingredient was higher;the effect of purification by high speed centrifugation was poor, but remaining ratio of active ingredient was also fine;the pharmacodynamic experiment results indicated that there were no remarkable difference between the two methods. Conclusion： Fifty percent alcoholpre- cipitation method is suitable for purification fructus citri sarcodactylis formula-granules.
出处
《中国药师》
CAS
2010年第4期462-464,共3页
China Pharmacist
基金
国家"十五"重大科技专项"创新药物和中药现代化"基金资助项目(编号:2001BA701A39)
关键词
广佛手
配方颗粒
除杂
胃排空
肠推进
Fructus cirri sarcodactylis
Formula-granules
Removing impurity
Gastric emptying
Small intestinal propulsive
