摘要
自然骨中的无机组分并不是纯的羟基磷灰石[(Ca10(PO4)6(OH)2,Hydroxyapatite,简称HA],还含有微量镁离子(Mg2+)、锌离子(Zn2+)等。为满足临床的需要,常常需要在HA中添加锌元素制成含锌羟基磷灰石(Zn-HA),其有望成为新一代的骨修复和替换材料。以硝酸钙、磷酸三铵、硝酸锌为原料,在210℃下水热处理8h合成Zn-HA和Ca19Zn2(PO4)14混合粉末。采用X射线衍射(XRD)、电子扫描电镜(SEM)和热重—差热分析(TG-DTA)法对合成粉体的晶相、形貌和热稳定性进行分析。结果表明:在210℃、8h的实验条件下,反应釜的填充度较大时容易合成Zn-HA,但Zn掺量的摩尔分数不宜超过4%;随着Zn掺量和反应釜填充度的增加,HA的结晶度下降;Zn的掺入促使HA易分解,使其热稳定性较差。
The inorganic component of natural bone does not occur as pure hydroxyapatite（HA） due to the presence of minor constituents such as Mg2 ＋ and Zn2 ＋ etc.The attempt to meet the requirements for clinical applications results in the necessity of substituting some Zn elements into the HA to prepare the zincsubstituted hydroxyapatite（Zn-HA）,which is expected to become the new generation of bone repair and replacement materials.This paper introduces the preparation of the mixture powders of Zn-HA and Ca19Zn2（PO4）14 by the hydrothermal method at 210 ℃ for 8 h,using Ca（NO3）2,（NH4）3PO4 and Zn（NO3）2 as the raw materials.Characterizing the crystalline phase,morphology,and thermal stability of the prepared powders by X-ray diffraction（XRD）,scanning electron microscopy（SEM） and thermogravimetric-diferential thermal analysis（TG-DTA） shows that the easy synthesis of Zn-HA results,in the case of the larger compactness of reactor at this 210 ℃、8 h experimental conditions,but the mole fraction of zinc incorporated is not over more than 4%.The decreasing crystallinity of HA is governed by the increasing Zn incorporated and the compactness of reactor.Easy decomposition of HA due to Zn addition results in its poor thermal stability.
出处
《黑龙江科技学院学报》
CAS
2010年第1期14-17,22,共5页
Journal of Heilongjiang Institute of Science and Technology
关键词
水热法
羟基磷灰石
锌
热稳定性
hydrothermal hydroxyapatite zinc thermalstability
