摘要
目的探讨子宫内膜异位症（EMs）患者腹腔液中生长相关性癌基因-1（GRO-α）、血管内皮生长因子（VEGF）的水平变化及其相关性。方法采用酶联免疫吸附试验（ELISA）检测39例内异症患者（EMs组）及25例非内异症患者（对照组）腹腔液中GRO-α及VEGF的水平。结果（1）在EMs组中，GRO-α、VEGF的水平分别为（108．77±20．58）ps／ml、（199．67±99．26）pg／ml，均高于对照组的（71．07±18．96）pg／ml、（115．46±32．39）pg／ml（P〈0．05～0．01）；（2）在EMs组中，III—IV期患者的GRO—α水平为（117．65±20．81）pg／ml高于I～II期患者的（99．43±16．05）Pg／ml，而III—IV期患者的VEGF水平为（154．82±54．55）pg／ml，低于I—II期患者的（246．894-114．34）pg／ml（P〈0．05～0．01）；（3）在EMs组中，GRO-α水平与r-AFS评分呈正相关（r=0．439，P〈0．05），而VEGF与r—AFS评分无相关（r=～0．210，P〉0．05）；（4）在EMs组中GRO-α、VEGF之间无相关（r=-0．05，P〉0．05）。结论腹腔液中GRO-α、VEGF的增高可能与内异症的发病有关；GRO-α与疾病的严重程度有关。
Objective To explore the changes of GRO-α and VEGF in the peritoneal fluid of women with endometriosis and their correlation. Methods The levels of GRO-α and VEGF were detected by enzyme linked immunosorhent assay （ELISA） method in 39 eases of endometriosis and 25 normal cases of without endometriosis. Results The levels of GRO-α and VEGF in the peritoneal fluid of EMs group were （108.77 ± 20. 58 ）pg/ml and （199. 67± 99.26）pg/ml separately, and it was significantly higher than those in control group （71.07 ± 18.96） pg/ml, （ 115.46± 32. 39） pg/ml. The differences were statically significant （ P 〈 0. 05 ）. The level of GRO-α in the peritoneal fluid of the patients in stage I and II was significantly lower than that in stage III and IV [ （ 99. 43 ± 16. 05 ） pg/ml vs （ 117. 65 ± 20. 8 ） pg/ml, P 〈 0.05 ], while the level of VEGF in the peritoneal fluid of the patients in stage I and II was significantly higher than that in stage III and IV [ （246. 89±114. 34）pg/ml vs （152. 82 ± 54. 55 ）pg/ml, P 〈 0. 05 ]. There was positive correlation between the level of GRO-ot and r-AFS （ r = 0. 439, P 〈 0. 05 ）, but no correlation between the level of VEGF and r-AFS （ r = - 0. 210, P 〉 0. 05 ）. There was no correlation be- tween peritoneal fluid levels of GRO-α and VEGF in the EMs group （ r = - 0. 05, P 〉 0. 05 ）. Conclusion Compared with control group, the levels of GRO-α and VEGF in peritoneal fluid of women with endometriosis were significantly increased, which indicated that the increased GRO-α and VEGF secretion involved in the pathogenesis of this disease. There was correlation between the peritoneal fluid level of GRO-α and the degree of EMs.
出处
《中国医师杂志》
CAS
2010年第2期149-152,共4页
Journal of Chinese Physician
