摘要
目的:观察人脑胶质瘤细胞SWO-38分泌产物对小脑皮质神经元生存和生长的影响。方法:SWO-38细胞与3天龄大鼠小脑皮质神经元联合培养。结果:SWO-38细胞对小脑皮质神经元的生存以及突起长度的增加有明显的促进作用。结论:SWO-38细胞可能释放对小脑皮质神经元有营养活性的神经营养因子。
Objective: To study the influence of human glioma cell line (SWO-38) on the survival and growth of 3-day-old rat cerebellar cortical neurons. Method: above-mentioned two kinds of cells were cocutured. Result: SWO-38 can significantly promote the survival of the neurons as well as increase the length of processes of the neurons. Conclusion: it is possible that the effects result from neurotophic factor released by SWO-38.
关键词
脑胶质瘤
小脑
皮质神经元
联合培养
生长
生存
Human brain glioma cell
Cerebellar cortical neurons
Coculture
Neu- rotrophic factor
