摘要
目的了解阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea-hypopnea syndrome，OSAHS）患者高血压发病情况及其程度，分析OSAHS对高血压患者血压昼夜节律的影响，从夜间低氧血症和睡眠结构方面探讨高血压发生的危险因素。方法采用多导睡眠监测仪对77例OSAHS患者（重度33例，中度23例，轻度23例）进行夜间7h睡眠监测和24h动态血压监测，对睡眠相关指标及不同时段血压进行分析，并与不伴OSAHS的高血压患者（15例）和正常对照者（15例）进行比较。结果（1）重度、中度和轻度OSAHS组体质指数（boay mass index,BMI）分别为（29．1±2．8）、（25．0±2．5）和（23．2±3．0）kg/m^2，均显著高于对照组的（20．3±4．1）kg/m^2（P均〈0．05）；睡眠呼吸暂停低通气指数（apnea hypopnea index，AHI）分别为（56．2±14．7）、（19．1±4．4）和（11．2±4．3）次／h，显著高于对照组的（2．9±1．0）次／h（P均〈0．05）；氧减指数（oxygen desaturation index，ODI）分别为（62．5±20．4）、（19．6±8．8）和（24．8±22．7）次／h，显著高于对照组的（2．7±2．0）次／h（（P均〈0．05））；微觉醒指数（microarousal index，MI）分别为（47．5±20．9）、（12．8±4．6）和（9．8±4．6）次／h，显著高于对照组的（1．3±1．1）次／h（P均〈0．05）；24h平均收缩压分别为（133±14．5）、（126±6．5）和（118±9．9）mmHg，重度和中度OSAHS组显著高于对照组的（117±9．6）mmHg（P均〈0．05）；24h舒张压分别为（92．8±9．6）、（86．3±7．5）和（81．9±3．9）mmHg，重度和中度OSAHS组显著高于对照组的（78．5±5．6）mmHg（P均〈0．05）；最低血氧饱和度分别为（65．5±10．4）％、（78．5±5．1）％和（79．7±9．6）％，重度和中度OSAHS组显著低于对照组的（84．7±8．2）％（P〈0．05）。（2）高血雎组与对照组睡前�
Objective To understand the incidence and the severity of hypertension in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and to analyze the impact of OSAHS on the circadian rhythm of blood pressure in patients with hypertension and to investigate the risk factors for the occurrence of hypertension from the aspects of nocturnal hypoxemia and sleep structure. Methods Polysomnography monitor was used for 7-hour sleep monitoring at night and 24-hour ambulatory blood pressure monitoring in 77 patients with OSAHS （severe, n =33; moderate, n =23; mild, n =23）. The sleep-related indicators and blood pressure at different times were analyzed, and they were compared to the patients with hypertension without OSAHS （n = 15） and normal controls （u = 15）. Results （1） The body mass index （BMI） in the severe, moderate, and mild OSAHS groups was 29. 1 ±2.8, 25.0 ±2.5, and 23.2 ±3.0 kg/m^2 respectively, and they were all significantly higher than 20.3 ± 4. 1 kg/m^2 in the control group （all P 〈0.05）; sleep apnea-hypopnea index （AHI） was 56.2 ± 14.7, 19.1 ± 4.4, and 11.2 ±4.3/h respectively, and they were significantly higher than 2.9 ± 1.0/h in the control group （all P〈0.05）; oxygen saturation index （ODI） was 62.5 ±20.4, 19.6 ±8.8, and 24. 8 ± 22.7/h respectively, and they were significantly higher than 2.7 ± 2.0/h in the control group （all P 〈0.05）; microarousal index （MI） was 47.5 ±20.9, 12.8 ±4.6, and 9.8 ±.6/h respectively, and they were significantly higher than 1.3 ± 1.1/h in the control group （all P 〈 0.05）; 24-hour mean systolic blood pressure was 133 ± 14.5, 126 ± 6.5, and 118 ± 9. 9 mm Hg respectively, and the severe and moderate OSAHS groups were significantly higher than 117 ±9.6 mm Hg （all P 〈0.05）; 24-hour mean diastolic blood pressure was 92.8 ±9.6, 86.3 ± 7.5, and 81.9 ± 3.9 mm Hg respectively, and the severe and moderate OSAHS groups were significantly higher than 78.5 ±5.6 mm Hg in the contr
出处
《国际脑血管病杂志》
北大核心
2010年第2期91-96,共6页
International Journal of Cerebrovascular Diseases
