摘要
本研究对４２例胃癌病例及４３例胃粘膜异型增生病例行Ｒａｓ癌基因Ｐ２１蛋白、抑癌基因Ｐ５３蛋白单克隆抗体免疫组化研究，结果发现胃癌组织中Ｐ２１阳性率为５４．７％，并与癌组织分化程度呈正相关。Ｐ５３蛋白阳性率为４２．８％，与癌组织分化程度呈负相关，说明胃癌组织中Ｐ２１蛋白及Ｐ５３蛋白的表达与其发生发展有重要关系，并与胃癌的生物学行为有关，在异型增生病例中Ｐ２１及Ｐ５３阳性多为重度病例，说明癌基因的激活与抑癌基因的突变在异型增生发生发展及癌变过程中起着重要作用。
Specimens of stomach from 42 cases of gastric carcinoma and 43 cases of gastric dysplasia were studied histologically and monoclonal antibodies against oncogenic protein P21and P53were used inmunohistochemically.The positively result of P21 in the tissus of gastric carcinoma is 54.7% and P53 is 42.8%.The positive result of P21 is directly related with the differentiation with the carcinoma while P53 is in contradictory.This indicated that the expression of P21 and P53 proteins in the gastric carcinoma is closely related to its biological behavior and progress.
