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心肌细胞兴奋-收缩耦联过程中钙离子调控的研究进展 被引量:2

Progress in Research of Ca^(2+) Signaling of Excitation-contraction Coupling in Cardiac Myocytes
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摘要 Ca2+作为细胞内重要的信使在心肌细胞兴奋-收缩耦联过程中起到重要作用,我们将钙离子对心肌细胞兴奋-收缩耦联过程的调控分为三个阶段:上游调控(胞浆中Ca2+升高),中枢调控(Ca2+与肌钙蛋白C结合),下游调控(粗细肌丝结合,形成横桥循环)。本文将对近几年发现的Ca2+在兴奋-收缩耦联过程中的调控作用进行介绍。 Cardiac calcium signal plays an important role in excitation-contraction coupling.The E-C coupling process can be classi?ed into three processes:upstream mechanism (Ca^2+ mobilization),central mechanism (Ca^2+ binding to troponin C),and downstream mechanism (Combination of thick and thin filaments,leading to crossbridge cycling).This review focuses on the three processes and the role of Ca^2+ in cardiac excitation-contraction (E-C) coupling in recent years.
出处 《科技信息》 2009年第31期51-52,共2页 Science & Technology Information
关键词 CA2+ 兴奋-收缩耦联 心肌细胞 Calcium Excitation-contraction coupling Cardiac myocytes
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参考文献15

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