摘要
目的探讨普通外科手术围手术期短程预防应用抗菌药物的有效性和可行性。方法520例普通外科手术患者随机分为观察组和对照组各260例,观察组头孢呋辛1.5g溶于100ml生理盐水,手术前30min开始静脉滴注,30min滴完,术后6h再给第2次;对照组,术后采用常规用药方案,回病房用头孢呋辛静脉滴注0.75g,2次/d,连续3d。结果两组术后发病率分别为7.31%、6.54%,最高体温(38.26±0.18)℃、(38.19±0.20)℃,体温正常时间(49.42±7.91)h、(48.29±8.12)h、切口感染率1.92%、3.08%等差异无统计学意义;观察组平均住院时间(15.86±2.31)d、术后住院时间(9.29±1.91)d低于对照组(17.92±2.78)d、(12.31±2.78)d,差异有统计学意义(P<0.05)。结论普通外科手术围手术期短程预防应用头孢呋辛,预防术后感染是一种合理有效而又经济的方案。
OBJECTIVE To explore the short-term effectiveness and feasibility of perioperative application of antibiotics in general surgery. METHODS All 520 cases of general surgical patients were randomly divided into two groups with equally 260 cases. In the test group cefuroxime （1.5g in 100ml saline）,was intravenously dripped 30 min before the surgery,30 min and 6 hours after the surgery gave second time. In control group,the conventional drug program was used after surgery with intravenous cefuroxime 0.75g,for 3d. RESULTS The postoperative infection rate of test and control groups was 7.31% and 6.54%,the highest fever was 38.26 ± 0.18 ℃ and 38.19±0.20℃,the temperature normalized was after 49.42±7.91h and 48.29± 8.12h,the incision infection rate was 1.92% and 3.08%,respectively etc. There was no significant difference between two groups; The total average length of stay and postoperative length of stay were 15.86±2.31 days and less than 9.29±1.91 days in test group vs 17.92±2.78 days and 12.31±2.78 days （P〈0.05）. CONCLUSIONS The perioperative short-term use antibiotics such as cefuroxime in general surgery is a reasonable,effective ,and economic madality for prevention of postoperative infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第5期703-704,共2页
Chinese Journal of Nosocomiology
关键词
普通外科
围术期
头孢呋辛
General surgery
Perioperative period
Cefuroxime
