摘要
目的探讨血清胱抑素C检测与99mTc-DTPA肾动态显像在早期糖尿病肾病中的诊断价值。方法按尿白蛋白排泄率将我院收治的己确诊2型糖尿病患者96例分为3组:糖尿病正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组,采用示踪剂99mTc-二乙胺五乙酸(99mTc-DTPA)检测肾小球滤过率,同时测定血清胱抑素C,血肌酐及糖化血红蛋白,并设立正常对照组27例。采用统计方法分析结果。结果99mTc-DTPA GFR在尿白蛋白正常组明显高于微量、大量白蛋白尿组和对照组(P<0.05);血清胱抑素C在微量及大量白蛋白尿组明显高于对照组及尿白蛋白正常的糖尿病组(P<0.05);血清胱抑素C与99mTc-DTPAGFR呈负相关(P<0.05)。结论99mTc-DTPA GFR及血清胱抑素C检测能更早的判断糖尿病肾脏损害程度,为糖尿病肾病临床分期提供依据。
Objective To probe into the clinical significance of isotope 99mTc-DTPA renal dynamic imaging and serum cystatin C （ScysC） in early diabetic nephropathy （DN） .Methods The study was performed on 96 type 2 diabetic patients from Affiliated Hospital of Jiangsu University. The patients were classified into three groups according to urine albumin excretion rate （UAER） as follows： the normal albuminuric, microalbuminuric and macroalbuminuric group. And other 27 healthy subjects were recruited as control group. ScysC, sermn creatinine （Scr）, isotope 99mTc-DTPA renal dynamic imaging and glycosylated hemoglobin（HbAlc） were measured in all patients. Results 99mTc-DTPA GFR levels was significantly higher in the normal albuminttric patients than those in the controls,the micro- and the macroalbuminuric group（ P 〈 0.05） ; ScysC levers was significantly higher in the micro- and the macroalbuminttric group than those in the controls and normal albuminuric patients; ScysC levels were nagetive-correlated with levels in the type 2 dia- betic patients（ P 〈 0.05）. Conclusion 99mTc-DTPA renal dynamic imaging and ScysC can be used as a marker to diagnose early diabetic nephropathy and to identify the stage of it.
出处
《中国实验诊断学》
北大核心
2010年第3期410-412,共3页
Chinese Journal of Laboratory Diagnosis
基金
江苏大学2008年度临床医学科技发展基金资助(编号:JLY20080030)
