摘要
目的:观察长QT间期综合征(LQTs)患者单用β-阻滞剂治疗与β-阻滞剂联合起搏器治疗的疗效对比。方法:对14例20岁以下心电图(ECG)QTC≥0.44s,有不能解释的晕厥症状或室性心律失常、心脏暂停伴有LQTs家族史的患者,采取了单用β-阻滞治疗(7例)和起搏器联合β-阻滞剂治疗(7例),并对其疗效进行了10年对比观察。结果:在10年的观察中,7例单用β-阻滞剂治疗的患者,ECG平均QTc仅缩短至(0.46±0.01)s,3例QTC≥0.44(<0.50)s者中有1例发生晕厥及心脏猝死(死亡)事件,2例发生晕厥及心脏暂停事件,其余4例TQC≥0.50(<0.60)s者发生晕厥或心脏猝死事件;7例QTC≥0.60s者采用了起搏器联合β-阻滞剂治疗,ECG平均QTc均缩短至0.44s以内的正常范围,无1例发生心脏骤停或猝死事件(P<0.01)。结论:对于出现不明原因反复发作的晕厥,ECG表现室性心动过速,伴有LQTs家族史,并有ECGQTc延长(≥0.44s)患者可采用起搏器联合β-阻滞剂治疗。
Objective：To studied the effect of treated with beta-blockers and beta-blockers combined implanted pacing on 14 petients with long QT syndrome（LQTs）.Methods：The 14 LQTs patients less than 20 years old were included,they were with LQTs（ECG QTC ≥0.44s）,unexplained syncope and ventricular arrhythmia. Seven patients only used with beta-blockers （beta-blockers group）and 7 patients used with beta-blockers combined implanted pacing （beta-blockers＋pacing group）,10 years follow-up.Results：The QTC only decreased to（0.46±0.01）s,all happen syncope,cardiac arrest or sudden,cardiac death in beta-blockers group,but in beta-blockers＋pacing group,the QTC decreased to 〈0.044 s（normal range）,no one happen cardiac arrest or sudden cardiac death（P〈0.01）.Conclusion：The effect of beta-blockers combined implanted pacing is more than that of only with beta-blockers for LQTs patients.
出处
《心血管康复医学杂志》
CAS
2010年第1期70-72,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
