摘要
目的:比较5种止吐方案对预防卵巢癌化疗所致呕吐的药物经济学分析。方法:对200例接受化疗的卵巢癌患者分为5组,分别用阿扎司琼氯化钠注射液(A组)、盐酸昂丹司琼(B组)、托烷司琼氯化钠注射液(C组)、雷莫司琼(D组)、格拉司琼氯化钠注射液(E组)预防化疗所致呕吐,观察其疗效并进行成本-效果分析。结果:5组止吐有效率分别为90%、95%、95%、90%、85%,成本-效果比分别为7.08、6.88、6.89、2.64、3.12、;以E组为参照,A、B、C、D组的增量成本-效果比分别为74.4、38.9、39.0、-5.4。结论:D组是预防化疗所致呕吐方案中较为合理的方案。
OBJECTIVE： To compare the pharmacoeconomic efficacy among five antiemetic schemes for preventing vomit induced by chemotherapy in patients with ovarian cancer.METHODS： A total of 200 patients with ovarian cancer were assigned to receive azasetron sodium chloride injection（group A）,ondansetron hydrochloride（group B）,tropisetron sodium chloride injection（group C）,ramosetron（group D）,or granisetron sodium chloride injection（group E） for preventing chemotherapy-induced vomiting.The therapeutic effects of the 5 groups were monitored and the cost-effectiveness analyses were conducted.RESULTS： For the 5 regimens,the effective rates were 90%,95%,95%,90%,and 85%,respectively;the cost-effectiveness ratios were 7.08,6.88,6.89,2.64,and 3.12,respectively.As against group E,the incremental cost-effectiveness ratios of group A,B,C,D were 74.4,38.9,39.0,and-5.4,respectively.CONCLUSION： The therapeutic regimen in group D was the most reasonable one among the five antiemetic schemes for prevention of chemotherapy-induced vomiting.
出处
《中国医院用药评价与分析》
2010年第1期36-37,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
卵巢癌
成本-效果分析
止吐
Ovarian cancer
Cost-effectiveness analysis
Antiemesis
