摘要
目的探讨佛手挥发油对哮喘动物的止咳、平喘、祛痰作用。方法采用水蒸气蒸馏法提取佛手挥发油,对实验组豚鼠和小鼠预先以高、中、低剂量的佛手挥发油(豚鼠用药剂量分别为1.080、0.540、0.108 g.kg-1,小鼠用药剂量分别为1.753、0.877、0.175 g.kg-1)灌胃,模型对照组动物则以9 g.L-1盐水灌胃,另外采用急支糖浆、氨茶碱、鲜竹沥为止咳、平喘、祛痰的阳性药物对照组。用药结束后观察各组在密闭玻璃实验测试箱内喷雾枸橼酸所致豚鼠引咳潜伏期、组胺喷雾致喘的潜伏期和腹腔注射苯酚红溶液后小鼠气管酚红排泌量。结果挥发油高、中、低剂量组和急支糖浆组引咳潜伏期均较模型组长(Pa<0.05,0.01)。挥发油高、中、低剂量组豚鼠在以组胺喷入致喘的潜伏期均较模型组长(Pa<0.05)。挥发油高、中、低剂量组气管酚红排泌量均显著大于模型组(Pa<0.05,0.01)。结论佛手挥发油对支气管哮喘动物具有止咳、平喘、祛痰等治疗作用。
Objective To explore the effect of bergamots volatile oil on relieving cough,asthma and eliminating phlegm in asthmatic rats and guinea -pig. Methods Bergamot essential oil was extracted by steam distillation,and the experimental guinea- pigs and mice were divi- ded into 3 groups with high, moderate and low doses of bergamot essential oil respectively （ 1. 080,0. 540,0. 108 g · kg^-1 for guinea pig, 1. 753, 0.877,0. 175 g · kg^- 1 for mice）. The other group were pre -treated with normal saline as model control group, and animals were fed with acute - brochisis - syrup,aminophylline,and xianzhuli oral -liquid as positive drug control groups. After the medication, the guinea pigs were sprayed with citric acid or histamine in a confined glass to induce cough or asthma,while the latent period of cough or asthma attack was detected. The mice were injected phenol red solution through the abdominal cavity,and the tracheal phenol red secretion volume was measured. Resets The latent period of cough in high ,moderate and low dose of bergamot volatile oil groups and acute - brochisis - syrup group were significantly longer than that of the model control group（ Pa 〈 0.05,0.01 ）. The latent period of asthma attack in experimental guinea pigs in high, moderate and low dose of bergamots volatile oil groups were all longer than that in model control group（Pa 〈0.05）. The phenol red excretion rate in mice -bronchi of the mice pre -treated with bergamot volatile oil were markedly higher than that in model control group （Pa 〈 0.05,0.01 ）. Conclusion The bergamot volatile oil is of beneficial to relieving cough ,asthma and eliminating phlegm in rats and guinea -pigs with bronchial asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第4期287-288,共2页
Journal of Applied Clinical Pediatrics
关键词
哮喘
佛手挥发油
豚鼠
小鼠
asthma
hergamot volatile oil
guinea - pig
rat
