摘要
目的了解引起下呼吸道医院感染的不动杆菌耐药现状及存在的危险因素。方法用常规的方法对下呼吸道的标本进行病原菌的培养及分离,用全自动微生物分析仪VITEK 2对细菌进行鉴定及药物敏感性试验,同时对由不动杆菌引发的158例院内感染患者的危险因素进行分析。结果不动杆菌引起下呼吸道医院感染相关的危险因素主要为使用糖皮质激素类药物或机械插管或患有糖尿病等;除亚胺培南、左氧氟沙星、头孢吡肟、头孢哌酮、头孢哌酮/舒巴坦及头孢他啶等对不动杆菌有较好的体外抗菌活性外(耐药率小于40.0%),临床常用的其他多种抗菌药物耐药较严重,耐药率均在40.0%以上。结论糖皮质激素,机械插管,糖尿病等是不动杆菌引起下呼吸道医院感染的主要危险因素,不动杆菌对临床常用的抗生素有多重耐药性。
Objective To study the current drug resistant situation and the risk factors of Acinetobacter in lower respiratory tract in nosocomial infection. Methods Bacteria strains from the lower respiratory tract were isolated by routine method. Identification of the bacteria and antibiotics susceptibility test were performed on VITEK2 all-automatic microbiology analysis system . The risk factors of 158 patients of Acinetobacter nosocomial infection were analysed at the same time. Results The risk factors of nosocomial Acinetobacter infections in lower respiratory tract were using glucocorticoid, mechanical ventilation, and state of diabetes. Antibiotics susceptibility test showed that the drug resistant rate of Acinetobacter to imlpenem, levofloxacin, piperaciUin, cefepime, cefoperazone, cefoperazon/sulbactam and ceftazidime was lower than 40.0% ; but was higher than 40.0% to many other antibiotics frequently used in clinic. Conclusions Risk factors for nosocomial infection with Acinetobacter in lower respiratory tract include using glucocorticoid, mechanical ventilation, and state of diabetes. Acinetobacter is multi-resistant to most antimicrobial agents.
出处
《中国微生态学杂志》
CAS
CSCD
2007年第5期448-449,共2页
Chinese Journal of Microecology
基金
广州市委科研重点攻关项目:2000-Z-027-01-2-3
关键词
不动杆菌
危险因素
医院感染
耐药性
Acinetobacter
Risk factors
Nosocomial infection
Drug resistance
