UnTTrapping the ends： A new player in overcoming protein linked DNA damage
UnTTrapping the ends： A new player in overcoming protein linked DNA damage
摘要
DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows these enzymes that need to break DNA to do so in a way that does not induce genome rearrangements or DNA damage responses. However, a variety of agents are able to trap topoisomerases while they are covalently bound to DNA.
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