摘要
目的分析与口腔鳞状细胞癌相关的临床病理指标,从中筛选出与颈淋巴结转移相关的危险因素。方法选择38例口腔鳞癌患者,对年龄、性别、发病部位、T分期、微血管密度等因素与淋巴结转移的关系进行统计学分析。结果有无淋巴结转移患者两组之间年龄、性别、病程、发病部位、病理分级的差异没有统计学意义[年龄(t=4.28)、性别(χ2=2.53)、病程(t=6.83)、发病部位(χ2=1.51)、病理分级(χ2=1.74),P均>0.05];有淋巴结转移组中T2期以上的例数及COX-2阳性表达率明显多于无淋巴结转移组(χ2分别=7.79、6.45,P均<0.05);有淋巴结转移组中的肿瘤浸润深度和微血管密度明显大于无淋巴结转移组(t分别=3.52、2.35,P均<0.05)。结论临床T分期、肿瘤浸润深度、微血管密度和COX-2表达的增加,是口腔鳞状细胞癌淋巴结转移的高危因素。
Objective To analyze the clinical pathological index related to the oral squamous cell carcinoma （OSCC）, and select risk factors coherent to neck lymphonode metastasis. Methods Selected 38 cases of OSCC, and the relationship among age, sex, onset site, T stage, microvessel density and lymphonode metastasis was analyzed. Results There were no differences of age, sex, course, location, pathology stage between metastasis group and nonmetastasis group （t=4.28, 6.83; X^2=2.53, 1.51, 1.74; P〉0.05）. The quantum of patients which were above T 2 and expressed COX-2 in metastasis group were more than non-metastasis group （X^2=7.79,6.45,P〈0.05）. The invasion depth and MVD of metastasis group were more than those of non-metastasis group （t =3.52,2.35 , P 〈0.05）. Conclusions T stage, cancer invasion depth, MVD and high expression of COX-2 were the risk factors of lymphonode metastasis of OSCC.
出处
《全科医学临床与教育》
2010年第1期23-25,共3页
Clinical Education of General Practice
关键词
口腔鳞状细胞癌
淋巴结转移
危险因素
oral squamous cell carcinoma
lymphonode metastasis
risk factors
