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米非司酮诱导围绝经期顽固性功能性子宫出血闭经35例疗效观察 被引量:8

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摘要 目的探讨米非司酮诱导围绝经期顽固性功能性子宫出血患者闭经的效果。方法对符合接受米非司酮治疗标准的35例患者,刮宫去除子宫内膜后开始服用米非司酮(10mg/d),连服3个月后观察诱导闭经效果,并检测血清性激素水平、血红蛋白及子宫内膜厚度。结果35例患者在用药期问全部闭经,停药后31例患者直接进入绝经期;治疗前与治疗后3个月血清中促卵泡生成素[(14.7±3.9)、(10.5±3.1)U/L]、促黄体生成素[(10.5±2.1)、(7.0±1.7)U/L]、雌二醇[(103.7±18.5)、(79.5±14.2)nmol/L]、泌乳素[(9.9±3.1)、(5.5±2.4)μg/L]、孕酮[(2.6±O.5)、(1.3±0.3)nmol/L]、睾酮[(0.6±0.2)、(O.3±0.1)μg/L]比较,差异均有统计学意义(P〈0.05);子宫内膜明显萎缩;贫血症状得到改善。结论米非司酮诱导围绝经期顽固性功能性子宫出血闭经效果显著,无明显不良反应,值得在临床推广应用。
作者 杨英 曹宠华
出处 《中国医师进修杂志》 2010年第3期32-33,共2页 Chinese Journal of Postgraduates of Medicine
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  • 1陈继兰.小剂量米非司酮治疗功能性子宫出血40例疗效观察[J].中国民康医学,2006,18(6):181-181. 被引量:2
  • 2杨蓓,田永杰,丁明霞.米非司酮和孕三烯酮对子宫内膜间质细胞生长增殖的影响[J].实用妇产科杂志,2007,23(7):419-421. 被引量:7
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