摘要
目的:探讨二甲双胍在治疗多囊卵巢综合征的临床效果。方法:30例多囊卵巢综合征(PCOS)患者,口服二甲双胍12周,采取自身对照,观察用药前、后临床症状、血清卵泡刺激素(FSH)、黄体生成激素(LH)、睾酮(T)、雄烯二酮(A2)、空腹血糖及空腹胰岛素水平的变化。结果:继发闭经13例中,7例恢复有排卵月经;月经稀发17例,10例恢复有排卵月经,不孕症16例,用药期间妊娠4例。用药后两组空腹胰岛素和雄激素水平均降低,比较差异有显著性(P<0.05)。结论:二甲双胍可有效改善PCOS患者的胰岛素抵抗状态,降低血中雄激素水平并恢复生育功能。
Objective: To investigate the clinical effects of metformin on treating women with polycystic ovary syndrome (P-COS). Methods; 30 of patients took orally metformin for 12 weeks. Clinical symptoms, FSH, LH, T, A2, glucose and insulin were measured before and after taking metformin. Results: Of 13 women with secondary amenorrhea, 7 got back catame-nia. 10 had catamenia again among 17 women with oligomenorrhea. 4 had a pregnancy in 16 of women with infertility. The content of insulin and androgen was less than that before taking medicine, and there was significant difference (P <0. 05). Conclusion: Metformin is effective to reduce the content of insulin and androgen and to recover ovulation in women with PCOS.
出处
《中国计划生育学杂志》
2004年第8期483-485,共3页
Chinese Journal of Family Planning
