摘要
目的比较西酞普兰与阿米替林治疗老年抑郁症的疗效和安全性。方法40例老年抑郁症患者,随机分两组,分别用西酞普兰和阿米替林治疗6周。采用汉密尔顿抑郁量表(HAMD)和副作用量表(TESS)于治疗前和治疗2、4、6周末分别评定疗效和不良反应。结果两组治疗后各周HAMD评分均较治疗前下降(P均<0.05);其中治疗后2周末,西酞普兰组评分下降较阿米替林组更明显,两组比较差异有显著性(P<0.05),但治疗4～6周末比较,差异均无显著性(P>0.05);西酞普兰组不良反应较阿米替林组少而轻。结论西酞普兰治疗老年抑郁症疗效与阿米替林相当,但起效较快,安全性高,不良反应轻微。
Objective To compare the efficacy and security of citalopram and amitriptyline in the treatment of senile depression. Methods 40 patients with senile depression were divided into two groups which were received citalopram or amitriptyline for 6 weeks respectively. And the curative effect and side reaction were evaluated with Hanmihon depressive scale （HAMD） and treatment emergent symptom scale（TESS） respectively before and after the treatment in 2nd,4th,6th weekend. Results The scores of HAMD decreased more markedly after the treatment than those before the treatment in two groups （ P 〈0.05 ） ; The scores of HAMD of the citalopram group decreased more markedly than those of the amitriptyline group after the treatment in 2nd weekend （ P 〈 0.05 ）, But there were no significant differences after the treatment in 4th, 6th weekend. The side reaction was less and slighter in citalopram group than that in mnitriplyline group. Conclusion Citalopram has a similar efficacy with amitriptyline in the treatment of the patients with senile depression, but the former arises faster, the security is higher, and the side reaction is slighter.
出处
《临床和实验医学杂志》
2010年第5期343-344,共2页
Journal of Clinical and Experimental Medicine
关键词
老年抑郁症
西酞普兰
阿米替林
治疗
Senile depression
Citalopram
Amitriptyline
Treatment
