摘要
目的研究氯诺昔康和羟丙基-β-环糊精(HP-β-CD)在pH7.4缓冲液中的相互作用及热力学特征。方法采用紫外-可见光谱扫描法研究氯诺昔康与HP-β-CD在溶液中的相互作用,采用摩尔连续递变法测定复合物化学计量学特征,根据溶解度相图斜率及截距测定热力学参数。结果氯诺昔康在HP-β-CD中的溶解相图为AL型,△H=-5.988 9 kJ.mol-1,△S=7.6305 J.mol-1.K-1。溶液中HP-β-CD影响氯诺昔康的紫外可见吸收特征,当其摩尔分数为0.5时,相同浓度氯诺昔康溶液的吸收度差异最大。结论HP-β-CD与氯诺昔康在溶液中存在明显的相互作用,复合物的化学计量学特征为1∶1(摩尔比),作用力主要为Van der Waals-London分散力和疏水性相互作用。
Objective To investigate the thermodynamic characteristics and interaction between lornoxicam and HP-β-CD in pH 7. 4 buffer. Methods UV-VIS scans were performed to study the effect of HP-β-CD on the absorption char- acteristics of lornoxicam. The complexation stoichiometry was determined by continuous variation plot technique （Job＇ s plot）. Phase solubility diagram was profiled according to Higuchi and Connors, and thermodynamic parameters （△H, △G and △S） were then computed from the slope and intercept of the line. Results The phase solubility dia- gram was AL type, △H=-5. 988 9 kJ · mol^- 1 , △S=7. 630 5 J · mol^- 1 · K ^-1. The difference of lornoxicam ah- sorption reached the maximum at a 0.5 mole fraction of HP-β-CD. Conclusion Significant interaction is found between lornoxicam and HP -β-CD in pH 7.4 PBS. The complexation stoichiometry is 1 ： 1. The driving force may be van der Waals-London dispersion force and hydrophobic interaction.
出处
《中南药学》
CAS
2010年第2期109-112,共4页
Central South Pharmacy
