摘要
目的:研究羟丙基-β-环糊精对二氢杨梅素(DMY)的增溶作用。方法:采用相溶解度法研究不同温度下羟丙基-β-环糊精对二氢杨梅素的包合作用,HPLC测定二氢杨梅素含量。结果:溶液中DMY与HP-β-CD质量浓度呈线性相关,相溶解度曲线呈AL型,包合物中DMY与HP-β-CD物质的量比1∶1,于25,35,45℃下表观稳定常数分别为500.0,944.8,2 449.8mol.L-1。结论:HP-β-CD对DMY有较好的增溶作用。
Objective：To study on solubilization of dihydromyricetin（DMY） by hydroxpropyl-β-cyclodextrin（HP-β-CD）.Method：Inclusion of HP-β-CD on DMY under different temperatures was investigated by phase-solubility method.The content of DMY was determined by HPLC.Result：With increasing of HP-β-CD in aqueous solution,solubility of DMY increased linearly,which showed typical AL-type phase solubility diagram.The molar ratio of DMY and HP-β-CD in the inclusion complex was 1∶ 1.The apparent stability constants of inclusion reaction at 25,35,45 ℃ were determined as 500.0,944.8,2 449.8 mol · L-1,respectively.Conclusion：The solubility of DMY was improved remarkably by HP-β-CD inclusion.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第9期12-14,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重大新药创新专项(2011ZX09401-009)
关键词
羟丙基-Β-环糊精
二氢杨梅素
相溶解度法
包合物
hydroxpropyl-β-cyclodextrin
dihydromyricetin
phase-solubility method
inclusion complex
