摘要
目的探讨慢性肾衰竭(CRF)并发上消化道黏膜病变的有效治疗方法。方法对42例CRF并发上消化道疾病患者和40例非CRF的上消化道疾病患者进行胃镜检查了解黏膜病变;随机对照研究麦滋林-S颗粒辅助治疗的临床疗效。结果CRF患者的上消化道症状与黏膜病变均较重,麦滋林-S结合泮托拉唑治疗20d后临床症状改善,胃镜下表现及病理组织学等方面均有不同程度的好转,发现麦滋林-S治疗组的治疗效果较对照组在CRF患者中有显著疗效(P<0.05)。结论CRF患者上消化黏膜病变较重,麦滋林-S结合泮托拉唑治疗具有显著疗效。
Objective To seek an effective therapy against upper gastrointestinal mueosal lesions in the patiens with chronic renal failure（CRF）. Methods The mucosal lesions were examined by gastroscopy in 82 patients with upper gastrointestinal symptoms,including 42 CRF patients and 40 non-CRF patients, the clinical efficacy was explored by a novel mucosal protective agents Marzulene-s in a randomized controlled trial. Results The symptoms and mucosal lesions were more serious in the CRF patients when compared with the control patients. Upper gastrointestinal symptoms were efficiently ameliorated and mucosal lesions were pathologically improved by pantoprazole combined Marzulene-s for over 20 days： Combination therapy（ combined Marzulene-s and pantoprazole） were more efficient than monotherapy（ with pantoprazole only） in the CRF patient （P 〈 0.05 ）. Conclusion The upper gastrointestinal mucosal lesions in the CRF patients were more serious and it was recommended to use pantoprazole combined with Marzulene-s.
出处
《中华全科医学》
2010年第3期298-299,共2页
Chinese Journal of General Practice
关键词
慢性肾衰竭
胃黏膜病变
麦滋林-S
治疗
Chronic renal failure
Gastrointestinal mucosal lesions
Marzulene-s
Therapy
