摘要
目的:观察清肾颗粒对慢性肾衰竭湿热证患者消化系统症状的改善及胃泌素水平的调节作用。方法:20例慢性肾衰竭湿热证患者,按随机数字表法,随机分为治疗组(西医基础治疗+中药灌肠+清肾颗粒)和对照组(西医基础治疗+中药灌肠)各10例。两组均予以西医基础治疗,治疗组加用清肾颗粒(皖药制字为BZ20080011)每次1包,每日3次,温水冲服。两组疗程均为2周。观察两组患者治疗前后中医证候积分值变化情况;治疗前后血肌酐(Scr)、eGFR(采用CKD-EPI公式计算)变化情况;治疗前后血清胃泌素-17(G-17)、胃蛋白酶原I/II水平变化。结果:治疗前,两组患者恶心、呕吐、肢体困重、食少纳呆、口干、口苦、脘腹胀满、口中粘腻中医证候积分值差异无统计学意义(P>0.05),治疗后,两组中医证候积分值均下降,且治疗组较对照组下降明显(P<0.05)。治疗前,两组患者Scr、eGFR水平差异无统计学意义(P>0.05),治疗后,两组Scr、eGFR水平均改善,且治疗组较对照组改善明显(P<0.05)。治疗前,两组患者血清G-17、PG I/II水平水平差异无统计学意义(P>0.05),治疗后,两组G-17、PG I/II水平均改善,且治疗组较对照组改善明显(P<0.05)。结论:清肾颗粒可以有效缓解慢性肾衰竭湿热证患者消化系统症状,保护肾功能,其机制可能是通过调节G-17、PG I/II水平实现的。
Objective:To observe the effect of Qingshen Granule on the improvement of digestive system symptoms and the regulation of gastrin level in chronic renal failure patients with damp heat syndrome.Methods:20 patients with damp heat syndrome of chronic renal failure were randomly divided into treatment group(basic treatment of Western medicine+enema of traditional Chinese medicine+Qingshen granule)and control group(basic treatment of Western medicine+enema of traditional Chinese Medicine)with 10 cases in each group.Both groups were given basic Western medicine treatment.The treatment group was additionally given Qingshen granules(Wanyao Zhizi:bz20080011),1 pack each time,3 times a day,and taken with warm water.The course of treatment was 2 weeks in both groups.The changes of TCM syndrome integral value,serum creatinine(SCR)and EGFR(calculated by CKD-EPI formula)before and after treatment,serum gastrin-17(G-17)and pepsinogen I/II levels before and after treatment were observed.Results:before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05),such as nausea,vomiting,heavy limbs,less food,dry mouth,bitter mouth,full abdominal distension and greasy mouth between the two groups(P>0.05).After treatment,the TCM Syndrome scores of the two groups were decreased,and the treatment group was significantly lower than the control group(P<0.05).Before treatment,there was no significant difference in SCR and EGFR levels between the two groups(P>0.05).After treatment,the levels of SCR and EGFR in the two groups were improved on average,and the improvement in the treatment group was more obvious than that in the control group(P<0.05).Before treatment,there was no significant difference in the levels of serum G-17 and PG I/II between the two groups(P>0.05).After treatment,the levels of G-17 and PG I/II in the two groups were improved,and the improvement in the treatment group was more obvious than that in the control group(P<0.05).Conclusion:Qingshen granule can effectively relieve diges
作者
张磊
王立媛
章雪莲
王亿平
ZHANG Lei;WANG Liyuan;ZHANG Xuelian;WANG Yiping(Department of Nephrology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《中医药临床杂志》
2020年第12期2339-2343,共5页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目及青年科学基金项目(81673931,82004165)
2016年安徽省中医发展专项资金:王亿平名中医工作室(卫办秘[2016]680号)
安徽中医药领军人才项目(中医药发展秘[2018]23号)
安徽中医药大学自然重点科研项目(2017fyzd007)。
关键词
清肾颗粒
慢性肾衰竭
湿热证
消化系统症状
胃泌素
Qingshen granule
chronic renal failure
damp heat syndrome
digestive system symptoms
gastrin
