摘要
目的了解b型流感嗜血杆菌(Hib)最易感人群体内Hib的特异性荚膜多糖(PRP)自然抗体水平,为Hib疫苗的推广使用提供依据。方法从柳州市常住3～59月龄健康婴幼儿中,抽取未接种过Hib疫苗的婴幼儿708名,采集血清标本,用ELISA方法检测Hib-PRP自然抗体水平。结果3～59月龄婴幼儿体内Hib-PRP自然抗体水平(0.1840.016)mg/L;3～35月龄婴幼儿体内Hib-PRP抗体水平与36～59月龄幼儿体内Hib-PRP抗体水平间差异有统计学意义(P<0.05)。各月龄儿童体内抗-PRP水平的保护程度间差异有统计学意义(P<0.05)。幼儿园儿童抗-PRP水平高于散居儿童(P<0.05);性别对婴幼儿体内Hib-PRP抗体水平没有影响(P>0.05)。结论对最易感人群接种Hib疫苗,提高体内Hib-PRP抗体水平,预防Hib感染性疾病是非常必要的。
Objective To study the natural level of antibody to Haemophilus influenzae type b （Hib） polyribosylribitol phosphate （PRP） of the crowd most easily infected by Hib, in order to provide a scientific basis for Hib immunization. Methods A total of 708 serum samples were collected from aged 3 - 59 months healthy infants who had not vaccinated Hib vaccine in Liuzhou city. The natural level of antibody to Hib - PRP was measured by ELISA. Results The natural level of anti- body to Hib - PRP was 0. 184 0. 016 in children aged 3 - 59 months. The Hib - PRP antibody levels of children aged 3 - 35 months was lower than that of children aged 36 - 59 months （ P 〈 0.05 ）. There were significant differences in Hib - PRP anti- body level among the children of different months （ P 〈 0. 05 ）. The kindergarten children had higher anti - PRP antibody titer than the children living scattered （ P 〈 0.05 ）. The sex factor was not correlated with Hib - PRP antibody level （ P 〉 0. 05 ）. Conclusion It is necessary to give Hib vaccination for the most susceptible crowd to raise the Hib - PRP antibody level to prevent Hib infection.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第6期632-633,共2页
Chinese General Practice
