摘要
目的:检测磷酸化活化转录因子2(p-ATF2)和磷酸化细胞信号传导与转录活化因子3(p-STAT3)在隆突性皮肤纤维肉瘤(DFSP)和皮肤纤维瘤(DF)中的表达。方法:采用免疫组化ABC法检测p-ATF2和p-STAT3分别在15例DFSP和18例DF皮损石蜡包埋切片中的表达。结果:在15例DFSP中,分别有13例和14例高表达p-ATF2和p-STAT3。而在18例DF中,分别有8例和6例表达p-ATF2和p-STAT3。DFSP中p-ATF2和p-STAT3的表达均显著高于DF中的表达(P<0.05)。在DFSP中,pATF2与p-STAT3阳性表达呈高度相关性(r=0.63,P<0.05)。结论:p-ATF2和p-STAT3在DFSP中呈高表达,提示它们在DFSP的发生和发展中可能起一定作用。
Objective： Investigate the expression of phosphorylated ATF2 （p- ATF2 ） and phosphorylated STAT 3 （p - SrAT 3） protein in DFSP and dermatofibroma and assess the relationships between them. Methods： 15 paraffin embedded DFSP specimens and 18 paraffin embedded dermatofibroma specimens were subjected to immunohistochemical staining for p- ATF2 and p- STAT3. Results： P- ATF2 was expressed in 13 out of 15 DFSP, and p - STAT3 was expressed in 14 out of 15 DFSP specimens. However, p- ATF2 was expressed in 8 out of 18 dermatofibroma specimens, and p - STAT3 was expressed in 6 out of 18 dermatofibroma specimens. The expressions of p - ATF2 and p - STAT3 in DFSP were significantly higher than those in dermatofibroma respectively （P 〈 0.05）. There was significant correlations between p - ATF2 and p - STAT3 expression （ r = 0.63, P 〈 0.05） in DFSP. Condusion： This study suggests that the overexpression of p - ATF2 and p - STAT 3 may play a pivotal role in the oncogenesis of DFSP.
出处
《中国麻风皮肤病杂志》
2010年第1期11-13,共3页
China Journal of Leprosy and Skin Diseases
