摘要
目的探讨糖皮质激素(GC)及其受体(GR)与分娩启动的关系。方法40例足月剖宫产孕妇均分为临产后剖宫产(A)组及选择性剖宫产(B)组。孕妇均无妊娠合并症及并发症,孕期未使用GC。检测血清及羊水中GC水平。采用免疫组化和RT-PCR技术检测胎盘、胎膜组织GR-α和GR-β的表达。结果A组血清GC水平明显高于B组(P<0.05)。两组胎盘组织几乎无GR表达;A组胎膜组织中GR-β表达明显低于B组,GR-α/GR-β比例高于B组(P<0.05)。结论临产后血清GC增加,胎膜上GR-β的表达降低,GR-α/GR-β增高,可能与分娩启动相关。
Objective To study the relationship between glucocorticoid（GC）,glucocorticoid receptors（GR）and the activation of delivery.Methods Fourty full-term pregnant women without using GC and having complications during pregnancy were divided into two groups with 20 cases each.The patients in group A were undergoing emergency Caesarean section and those in group B selective Caesarean section.The blood and amniotic fluid samples were collected for detecting GC using radioimmunity.GR-α and GR-β in the placenta and fetal membrane were determined using immunohistochemistry and RT-PCR.Results The serum GC was higher in group A than that in group B（P〈0.05）.There was almost no GR expression in the placenta.The GR-β expression level in the fetal membrane in group A was lower than that in group B with an increase in the ratio of GR-α to GR-β（P〈0.05）.Conclusion The increased GC levels in serum,the decreased GR-β in the fetal membrane and the increased ratio of GR-α to GR-β in fetal membrane may be correlated with the activation of delivery.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第1期11-14,共4页
Jiangsu Medical Journal
关键词
糖皮质激素
糖皮质激素受体
分娩发动
Glucocorticoid Glucocorticoid receptor Delivery activation
