摘要
利用酚酞作为光谱探针,竞争光度法研究了β-环糊精衍生物在室温下,pH=10.38的缓冲液中与硫唑嘌呤和巯嘌呤的包合性能。固定β-环糊精衍生物和酚酞的浓度,随着硫唑嘌呤和巯嘌呤两种药物浓度增大,酚酞的紫外吸收增加,表明β-环糊精衍生物与两种嘌呤类药物形成包合物并得出了包合常数。
The competitive UV-Vis spectrophtometric method was applied to study the inclusion interaction and determine the inclusion constant of β-CD derivatives with two anticancer xanthines with phenolphthalein as a spectral probe in aqueous buffer solution （pH = 10. 38） at room temperature, determine the inclusion constants of 6-MP, BAN and β-Cyclodextrin （β--CD）＇s derivatives, β-CD＇s derivatives can include two anticancer xanthines to form the inclusion compounds. The different inclusion stability constants of β-CD＇s derivatives encapsulating two anticancer xanthines were given.
出处
《光谱实验室》
CAS
CSCD
北大核心
2009年第6期1650-1653,共4页
Chinese Journal of Spectroscopy Laboratory
基金
山西高校科技研究开发项目(200713006)
山西医科大学学生创新项目(201231)资助
关键词
硫唑嘌呤
巯嘌呤
Β-环糊精
酚酞
竞争包结
Azathioprine （BAN）
6-Mercaptopurine （6-MP）
β-Cyclodextrin
Phenolphthalein
Competitive Inclusion
