摘要
目的了解郑州某高校新生中两种国产乙型肝炎（乙肝）疫苗预防接种的效果。方法采用单纯随机抽样方法，将743名新生分为两组，分别接种重组乙肝疫苗（CHO细胞）和重组乙肝疫苗（汉逊酵母），剂量均为10μg／0．5ml，按0、1、6个月免疫程序接种。免疫后2个月，检测血清抗-HBs滴度，比较两种疫苗组的抗体阳转率和几何平均浓度（GMC）。组间比较采用χ2检验。结果重组乙肝疫苗（CHO细胞）组的抗体阳转率为87．14％，重组乙肝疫苗（汉逊酵母）组的抗体阳转率为97．20％，两组间差异有统计学意义（χ2=6．28，P〈0．05）。两组疫苗的抗-HBsGMC分别为1489．72和2265．68IU／L。结论国产重组乙肝疫苗（汉逊酵母）预防接种效果良好，应大力推广使用。
Objective To evaluate immunization effects of two kinds of domestic recombinant hepatitis B vaccines in college freshmen. Methods A total of 743 freshmen were randomly divided into recombinant hepatitis B vaccine （CHO cell） group and recombinant hepatitis B vaccine （Hansenula polymorpha） group, and the freshmen in each group were immunized with 3 doses of the corresponding vaccine 10 μg/0.5 ml at a schedule of 0, 1, and 6 months. Serum anti-HBs titer was measured 2 months after the last vaccination, and 2 antibody positive rates and geometric mean concentration （ GMC ） were compared between the two groups. χ2 test was adopted in the comparison between the two groups. Results Antibody positive rates were 87.14% in recombinant hepatitis B vaccine （CHO cell） group and 97.20% in recombinant hepatitis B vaccine （Hanse- nula polymorpha） group, and there was a statistically significant difference between the two groups（χ2 = 6. 28, P 〈 0.05）. Anti-HBs GMCs were 1489.72 and 2265.68 IU/L,respectively, in the two groups. Conclusion The effect of recombinant hepatitis B vaccine （Hansenula polymorpha） is good, which can be used widely.
出处
《国际生物制品学杂志》
CAS
2010年第1期14-15,共2页
International Journal of Biologicals
关键词
肝炎疫苗
乙型
接种
人群监测
Hepatitis B vaccine
Vaccination
Population surveillance
