摘要
目的观察新生儿接种国产重组乙型肝炎（乙肝）疫苗[中国仓鼠卵巢细胞（CHO细胞）]后1～8年免疫效果。方法2005年9～10月在4个试点乡对1997～1999年出生的儿童全部采集血清标本，检测乙肝病毒表面抗原（HBsAg）、乙肝病毒表面抗体（抗-HBs）和乙肝病毒核心抗体（抗-HBc）。结果免疫后1～8年，抗-HBs阳性（S／N≥2．1）率平均为91．95％，有效抗-HBs阳性（S/N≥10．0）率为75．74％，抗体S／N值几何平均浓度（GMC）为30．14毫国际单位／毫升。总的趋势是抗体阳性率和GMC随免疫年限延长逐渐降低。HBsAg阳性率为0．67％，抗-HBc阳性率为1．39％，未见HBsAg随免疫年限延长而逐渐升高的现象。结论国产重组乙肝疫苗（CHO细胞）免疫后1～8年抗体持久性下降，但保护效果良好。
Objective To investigate immune effect of homemade recombinant Hepatitis B vaccine to new born baby after inoculating 1-8 years. Methods Based on the investigation of short-term effect of inoculating to new born baby with recombinant Hepatitis B vaccine （CHO）, the serum samples of all children born from 1997 to 1999, who live in 4 villages of 7 experimental villages, were collected. HB- sAg, anti-HBc and anti-HBs were detected by ELISA. Results After 8 years inoculating, the average positive rate of anti-HBs is 91.95 %. The effective positive rate of anti-HBs is 75.74 %. The geometry mean concentration （GMC） of SAN of anti-HBs is 30.14. The general tendency is that the GMC and positive of anti-HBs descend gradually with the prolongation of time. In this study, HBsAg and anti-HBc positive rates are 0.67 %, 1.39 % respectively. No ascent was found. Conclusion Both the protection efficacy and persistence of anti-HBs of homemade recombinant Hepatitis B vaccine （CHO） are very well to new born baby after 1-8 years inoculating .
出处
《中国计划免疫》
2007年第1期12-14,共3页
Chinese Journal of Vaccines and Immunization
