摘要
本文采用海马内微量注射褪黑素（ｉｈ，ＭＴ）的技术，发现ｉｈＭＴ具有明显的免疫调节作用。进一步发现，ｉｈＭＴ能提高海马内去甲肾上腺素水平，通过α２受体，交感神经系统调节免疫功能。本研究还发现，脾细胞能产生ＭＴ，脾细胞中可能存在着ＭＴ合成的关键酶。ｉｈＭＴ能通过交感神经系统去甲肾上腺素能神经，促进脾细胞产生ＭＴ，由此诱导βＥｎｄ调节免疫功能，ｉｈＭＴ还能通过海马去甲肾上腺素作用α２受体，反馈抑制松果体ＭＴ的产生，表明海马与松果体之间可能存在着反馈调节回路。
This paper reports that melatonin(MT) microinjected into hippocampus (ih) produces immunoregulatory actions. In ih MT rats, the contents of norepinephrine (NE) were increased in the hippocampus, and the immunologic effects of the ih MT could be related to α 2 adrenergic receptors of sympathatic systems. It was also found that MT could be produced by the splenocytes where the two key enzymes (NAT, HIMOT) exist. The immunoregulatory actions of ih MT could be related to the increased production of MT in the splenocytes, which induced the release of β Endorphin. The increased NE in the hippocampus in ih MT rats, could inhibit the release of MT in pineal gland and the actions may also be mediated through α 2 adrenergic receptors. The result suggested that a feed back circuit may exist between the hippocampus and the pineal, which balances the immunologic function in the body.
出处
《生理科学进展》
CAS
CSCD
北大核心
1998年第4期331-334,共4页
Progress in Physiological Sciences
