摘要
蛋白酶激活受体-2(proteinase-activated receptor,PAR)是G蛋白耦联受体家族成员之一,遍布整个胃肠道上皮细胞表面,易暴露于能使其激活的蛋白酶中,是体内许多消化道腺体外分泌的直接调控者,直接影响胃肠道动力。目前,蛋白酶激活受体独特的激活方式及其在消化系统中的广泛分布和复杂多样的生理作用,特别是蛋白酶激活受体-2与胃肠运动和感知的关系正受到广泛关注。
Proteinase activation receptor-2 （PAR-2） is one of the G protein coupling receptor family members. It exists in all over the epithelial cell surface of gastrointestinal tract, and is easy to expose to the proteinase that can activate it. It is a direct exocrine regulator of many digestive glands, arid directly affects the capability of gastrointestinal tract. At present, the PAR-2＇s unique activation way, its wide distribution in digestive system and its complicated physiological functions, especially the relation between PAR-2 and the gastrointestinal movement and perception, are being highly concerned.
出处
《医学研究生学报》
CAS
2010年第1期97-101,共5页
Journal of Medical Postgraduates
基金
武警医学院科研基金(WBS2007-1)
关键词
蛋白酶激活受体-2
胰蛋白酶
胃肠道
运动
感知
Proteinase activation receptor-2
Proteinase
Gastrointestinal tract
Movement
Perception
