期刊文献+

高脂饮食对非酒精性脂肪肝影响机制研究进展 被引量:29

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摘要 本文从高脂饮食容易引起胰岛素抵抗,影响脂质代谢的关键核转录因子从而调控相关蛋白酶的表达和活性,以及氧化过程中可能导致的脂质过氧化三个方面,综述了高脂饮食对肝脏脂质氧化代谢的影响。
出处 《实用肝脏病杂志》 CAS 2010年第1期72-74,共3页 Journal of Practical Hepatology
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参考文献20

  • 1ZAFRA NI ES. Non-alcoholic fatty liver disease:an emerging pathological spectrum[J]. Virchows Arch,2004, 444(1):3-12. 被引量:1
  • 2高爱滨,肖谦.PPARα与非酒精性脂肪肝[J].国际消化病杂志,2007,27(1):18-21. 被引量:9
  • 3ANAI M,FUNAKI M,OGIHARA T,et al. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats [J]. Diabetes, 1998,47( 1 ) : 13-:23. 被引量:1
  • 4GRIFFINN ME,MARCUCCI MJ,CLINE GW,et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade [J]. Diabetes,1999,48(6): 1270-1274. 被引量:1
  • 5BODEN G. Role of fatty acids in the pathogeuesis of insulin resistance and NIDDM [J]. Diabetes, 1997,d6( 1 ) : 3-10. 被引量:1
  • 6POLYZOS SA,KOUNTOURAS J,ZAVOS C. Nonalcoholic fatty liver disease:the pathogenetic roles of insulin resistance and adipocytokines [J]. Curr Mol Med,2009,9(3): 299-314. 被引量:1
  • 7杨丽丽,柳涛,王淼,邢练军,季光,郑培永.氧化应激与非酒精性脂肪性肝病研究进展[J].世界华人消化杂志,2009,17(9):896-900. 被引量:30
  • 8GARCIA-ROVES P,JANICE MH,DONG HH,et al. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle [J]. PNAS, 2007,104(25): 10709-10713. 被引量:1
  • 9CHAKRABARTI R,VIKRAMADITHYAN RK,MISRA P, et al. Ragaglitazar:a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models [J]. Br J Pharmacol,2003,140(3):527-537. 被引量:1
  • 10BAUMGARDNER JN,SHANKAR K,HENNINGS L,et al. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a highpolyunsaturated fat diet [J]. Am J Physiol Gastrointest Liver Physio, 2008,294 : G27-G38. 被引量:1

二级参考文献101

  • 1陈岳祥,刘苏,曾欣,谢渭芬.牛磺酸治疗非酒精性脂肪肝19例临床观察[J].中国实用内科杂志,2005,25(3):249-250. 被引量:14
  • 2曾民德.脂肪性肝病的氧应激及其治疗对策[J].国外医学(消化系疾病分册),2005,25(5):263-266. 被引量:15
  • 3Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):161-163. 被引量:1515
  • 4于晓静,王晓梅,冯海娟.2型糖尿病合并脂肪肝危险因素临床分析[J].世界华人消化杂志,2006,14(30):2977-2979. 被引量:16
  • 5Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI.Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes.Diabetes 2005; 54: 603-608 被引量:1
  • 6Angulo P.Nonalcoholic fatty liver disease.N Engl J Med 2002; 346: 1221-1231 被引量:1
  • 7Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI.Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.J Biol Chem 2004; 279: 32345-32353 被引量:1
  • 8Lai E, Teodoro T, Volchuk A.Endoplasmic reticulum stress: signaling the unfolded protein response.Physiology (Bethesda) 2007; 22: 193-201 被引量:1
  • 9Araki E, Oyadomari S, Mori M.Endoplasmic reticulum stress and diabetes mellitus.Intern Med 2003; 42: 7-14 被引量:1
  • 10Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, G?rgün C, Glimcher LH, Hotamisligil GS.Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.Science 2004; 306: 457-461 被引量:1

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