摘要
目的探讨急性冠状动脉综合征(ACS)患者血浆氧化脂蛋白(a)[ox-Lp(a)]水平的变化及机制。方法分别检测96例ACS、89例非ACS患者和100例健康人血浆ox-Lp(a)水平,冠状动脉造影确认冠状动脉病变程度。结果ACS组和非ACS组ox-Lp(a)水平均高于对照组,且ACS组ox-Lp(a)水平显著高于非ACS组。ACS组ox-Lp(a)/Lp(a)比值高于非ACS组和健康对照组,后两者中该比值无显著差别。ACS患者中ox-Lp(a)水平与冠状动脉病变程度相关(r=0.370,P=0.000),非ACS组中两者不相关(r=0.051,P=0.634)。多因素分析显示,ox-Lp(a)、TG水平及年龄解释ACS患者15.1%的病变程度。结论高ox-Lp(a)水平与ACS的发生、病变程度有关,有益于鉴别ACS。
Objective To investigate the association of increased oxidized lipoprotein（a） [ ox-Lp（a） ] levels with the severity of acute coronary syndromes （ACS） and relevant possible mechanisms. Methods Ox-Lp （a） levels were measured in 96 ACS patients, 89 non-ACS patients, and 100 healthy subjects. The extent of coronary artery disease （CAD） was determined by coronary angiography. Results Ox-Lp（a） levels significantly increased in ACS or non-ACS patients, compared with those in control. ACS patients had higher ox-Lp（a） levels than non-ACS patients. The ratio of ox-Lp（a） to Lp（a） in ACS was higher than that in either non-ACS or control, whereas the ratio was comparable between the non-ACS and control. Ox-Lp （a） levels were found to be associated with a graded increase with the severity of CAD in the ACS （ r = 0. 370, P =0. 001 ）, yet not in the non-ACS （ r = 0.051, P = 0.634）. Multiple linear regression analysis showed that ox-Lp（ a）, triglyceride, and age accounted for 15.1% of the variation in the severity of CAD in ACS patients. Conclusions Elevated ox-Lp（a） levels are associated with the presence and severity of ACS, and testing ox-Lp （a） may be useful in identifying ACS patients.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2010年第1期24-26,共3页
Chinese Journal of Clinical Laboratory Science
基金
国家自然科学基金资助项目(30872411和30471649)
关键词
脂蛋白
氧化
动脉粥样硬化
急性冠状动脉综合征
冠心病
lipoproteins
oxidation
atherosclerosis
acute coronary syndrome
coronary artery disease
