摘要
目的检测、分析SLE患者血清氧化低密度脂蛋白(ox-LDL)水平。方法采用ELISA检测47例SLE患者和42例健康对照者血清ox-LDL,同时对受检者常规血脂水平进行测定。结果SLE患者ox-LDL水平显著高于对照组[(143.40±65.36)mg/L vs(65.77±26.19)mg/L,P<0.01],总胆固醇、三酰甘油、LDL-胆固醇(LDL-C)和载脂蛋白B(apo B)等常规血脂水平也明显升高。以对照组ox-LDL水平的x-+s值为cut off值,SLE组37例高于此值(敏感性78.7%),健康对照组6例异常(特异性85.7%)。多因素分析显示,患者组ox-LDL水平与LDL-C显著正相关。结论SLE患者血清ox-LDL水平升高,检测ox-LDL水平有助于预测SLE患者As的发生风险。
Objective To measure and analyze serum oxidized low density lipoprotein （ox-LDL） concentration in systemic lupus erythematosus （SLE） patients. Methods The concentrations of ox-LDL were studied in 47 SLE patients and 42 healthy controls with an ELISA assay and serum lipoproteins levels were also determined. Results Serum ox-LDL levels were significantly elevated in SLE patients compared with those in controls [ （143.40 ± 65.36） mg/L vs （65.77± 26.19） rag/L, P 〈 0.01 ]. The concentrations of total cholesterol, triacyglycerols, LDL-cholesterol （LDL-C）, and apolipoprotein B were also markedly higher in SLE than in controls. Thirty seven patients （ sensitivity of 78% ） were found to have elevated ox-LDL concentrations, whereas only 6 of 42 controls （ specifici- ty of 86% ） had high ox-LDL levels. When multiple linear regression analysis was performed, LDL-C concentration was found to be the only variable showing a significant correlation with ox-LDL level in SLE group. Conclusions ox-LDL levels are significantly elevated in SLE patients, which is an important risk factor for predicting atherosclerosis in the patients.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2010年第2期116-118,共3页
Chinese Journal of Clinical Laboratory Science
基金
国家自然科学基金资助项目(批准号:NSFC30872411
NSFC30950100)
关键词
低密度脂蛋白
氧化修饰
血脂
系统性红斑狼疮
动脉粥样硬化
危险因素
low density lipoprotein
oxidative modification
serum lipids
systemic lupus erythematosus
atherosclerosis
risk factor
