摘要
目的：比较西替利嗪与阿司咪唑治疗常年变应性鼻炎的疗效。方法：将常年变应性鼻炎病人７４例（男性３４例，女性４０例，年龄３５±ｓ１０ａ）随机分为西替利嗪治疗组４３例和阿司咪唑对照组３１例。治疗组与对照组分别口服西替利嗪和阿司咪唑各１０ｍｇ／ｄ×１０ｄ，并辅以０．５％可的松和１％麻黄碱滴鼻，每日２～３次。结果：治疗组和对照组总有效率分别为９５％与８１％（Ｐ＞０．０５）。１ｈ内治疗组起效４０例，对照组３例（Ｐ＜０．０１）。治疗组嗜睡１例，对照组６例（Ｐ＜０．０５）。结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。
AIM: To compare the effects of cetirizine vs astemizole in treating perennial allergic rhinitis. METHODS: Seventy four patients (M 34, F 40; age 35±s 10 a) were randomly divided into 2 groups, 43 patients in cetirizine group received cetirizine 10 mg, po, qd, for 10 d and 31 patients in astemizole group received astemizole 10 mg, po, qd, for 10 d. Both groups were received nasal administrations with 0.5% cortisone and 1% ephedrine, bid or tid, for 10 d. RESULTS: The total effective rates were 95% in cetirizine group and 81% in astemizole group (P>0.05). Forty patients of cetirizine group and 3 of astemizole group were effective in 1 h (P<0.01), 1 patient of cetirizine group and 6 of astemizole group had adverse reactions of sleepiness. CONCLUSION: The effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第5期290-291,共2页
Chinese Journal of New Drugs and Clinical Remedies
