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托烷司琼不同给药方式对老年患者硬外镇痛后恶心呕吐的防治 被引量:1

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摘要 目的观察托烷司琼不同给药方式对骨科手术后硬膜外自控镇痛(PCEA)恶心呕吐的防治效果。方法选择ASAⅠ-Ⅱ级腰硬联合麻醉的老年骨科手术病人120例,术毕行芬太尼、罗哌卡因PCEA。随机分为6组:Ⅰ组(对照组)不给止吐药;Ⅱ组麻醉前静注托烷司琼4 mg;Ⅲ组术毕静注托烷司琼4 mg;Ⅳ组麻醉前给予托烷司琼2 mg,6 h后再静注2 mg;Ⅴ组术毕静注托烷司琼2 mg,镇痛泵给予2 mg;Ⅵ组静脉镇痛泵给予4 mg。观察各组术后8 h、12 h、24 h、36 h、48 h病人恶心呕吐发生情况。结果Ⅱ、Ⅳ组0-24 h止恶心呕吐作用明显优于其他四组(P<0.05);Ⅲ、Ⅴ组前8 h恶心呕吐发生程度较Ⅱ、Ⅳ组高(P<0.05);Ⅵ组8 h、12 h恶心呕吐发生率较Ⅱ、Ⅲ、Ⅳ、Ⅴ组高(P<0.05)。结论术前给予托烷司琼4 mg、2 mg可更有效防止老年骨科手术患者术后用芬太尼PCEA引起的恶心呕吐。
出处 《海南医学》 CAS 2010年第3期43-44,共2页 Hainan Medical Journal
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