摘要
Hepcidin是调节机体铁稳态的一类抗菌多肽。在炎症和感染时,炎性细胞因子可直接刺激肝脏表达合成hepcidin,通过hepcidin负性铁调节作用,抑制单核-巨噬细胞系统铁释放和肠道铁吸收,最终导致低铁血症,诱发贫血。随着对hepcidin的不断研究,针对hepcidin信号转导途径的特异性的靶向治疗,从分子角度切断铁的不足,纠正低铁血症将给铁代谢紊乱相关疾病如慢性病贫血的治疗带来新的希望。
Hepcidin is an antibacterial polypeptide which plays an important role in regulating iron homeostasis in human body.In the process of inflammation or infection,inflammatory cytokines can directly act on hepatic cells thus stimulate the expression and synthesis of hepcidin,which can inhibit iron release by the mononuclear phagocyte system as well as iron absorption in intestinal tract.This negative iron regulatory effect will lead to hypoferremia and anemia eventually.With further studies being carried out on hepcidin, it is firmly believed that a specific targeted therapy ,which aims at signal transduction pathways of hepcidin, will break the circle of iron deficiency and hypoferremia at a molecular level, hence bring about revolutionary changes in the treatment of iron metabolic disorder related diseases, such as anemia of chronic disorders.
出处
《医学综述》
2010年第1期45-47,共3页
Medical Recapitulate
