摘要
目的:了解我院药品不良反应(ADR)的发生规律及特点,为临床合理用药提供参考。方法:对我院2008年上报的270例ADR报表按患者年龄、性别、给药途径、药品种类、ADR累及器官或系统及临床表现等进行统计分析。结果:270例ADR中,男性132例(48.89%),女性138例(51.11%),年龄最小8个月,最大72a,<10a和>60a患者人数明显高于其他年龄段;静脉滴注发生率较高(51.85%);抗菌药物引起ADR比例最高(58.52%),尤以头孢菌素类多见,其次为中药注射剂(19.26%);临床表现以皮肤及附件损害为主;新的和严重的ADR共8例(2.96%)。结论:重视抗菌药物及中药注射剂的使用,加强ADR监测,以减少ADR的发生。
Objective： To investigate the characteristics and pattern of adverse drug reactions （ADRs） occurred in our hospital and provide reference for rational drugs use in clinic. Methods： There were 270 ADR reports collected from our hospital in 2008, which were analyzed statistically in respect of patients＇ age and sex, routes of administration, drugs categories, organs and systems involved and clinical manifestations. Results： Among the 270 ADR cases, 132 cases （48.89%） were male, 138 cases （5 1. 11%） were female. The youngest patient was 8 months and the eldest was 72 years old. The incidence rate of ADRs in the patients under 10 years old and above 60 years old were higher than other age groups. Intravenous drip was the main route of administration, accounting for 51.85%. Antibacterials （58.52%） occupied the highest proportion in ADRs, and cephalosporins were the main ADRinducing antibacterials, followed by traditional Chinese medicine injection （19.26%）. Lesions of skin and its appendants were the main clinical manifestations. There were 8 cases involved in new or serious ADRs, occupying 2.96%. Conclusion： The rational use of antibacterials and traditional Chinese medicine injection should be paid more attention to, and the monitoring of ADRs should be strengthened in order to decrease the occurrence of adverse drug reactions.
出处
《中国药物应用与监测》
CAS
2010年第1期40-42,共3页
Chinese Journal of Drug Application and Monitoring
关键词
药品不良反应
监测
合理用药
Adverse drug reaction
Monitoring
Rational drug use
