摘要
Objective To review the role of cyclic adenosine monophosphate （cAMP） signal pathway in the pathogenesis of iymphoma and explore a potential lymphoma therapy targeted on this signaling pathway. Data sources The data cited in this review were mainly obtained from the articles listed in Medline and PubMed, published from January 1995 to June 2009. The search terms were ＂cAMP＂ and ＂lymphoma＂. Study selection Articles regarding the role of the cAMP pathway in apoptosis of lymphoma and associated cells and its potential role in targeted therapy of lymphoma. Results In the transformation of lymphocytic malignancies, several signal pathways are involved. Among of them, the cAMP pathway has attracted increasing attention because of its apoptosis-inducing role in several lymphoma cells, cAMP pathway impairment is found to influence the prognosis of lymphoma. Targeted therapy to the cAMP pathway seems to be a new direction for lymphoma treatment, aiming at restoring the cAMP function. Conclusions cAMP signal pathway has different effects on various lymphoma cells, cAMP analogues and phosphodiesterase 4B （PDE4B） inhibitors have potential clinical significance. However, many challenges remain in understandinq the various roles of such agents.
Objective To review the role of cyclic adenosine monophosphate （cAMP） signal pathway in the pathogenesis of iymphoma and explore a potential lymphoma therapy targeted on this signaling pathway. Data sources The data cited in this review were mainly obtained from the articles listed in Medline and PubMed, published from January 1995 to June 2009. The search terms were ＂cAMP＂ and ＂lymphoma＂. Study selection Articles regarding the role of the cAMP pathway in apoptosis of lymphoma and associated cells and its potential role in targeted therapy of lymphoma. Results In the transformation of lymphocytic malignancies, several signal pathways are involved. Among of them, the cAMP pathway has attracted increasing attention because of its apoptosis-inducing role in several lymphoma cells, cAMP pathway impairment is found to influence the prognosis of lymphoma. Targeted therapy to the cAMP pathway seems to be a new direction for lymphoma treatment, aiming at restoring the cAMP function. Conclusions cAMP signal pathway has different effects on various lymphoma cells, cAMP analogues and phosphodiesterase 4B （PDE4B） inhibitors have potential clinical significance. However, many challenges remain in understandinq the various roles of such agents.
基金
This study was supported by the grants from the Natural Science Foundation of Shandong Province, China （No. Y2007C053） and the Project of Scientific and Technological Development of Shandong Province, China （No. 2007GG10002008）.
