摘要
目的探讨血清总前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA)和游离与总前列腺特异抗原比值(F/T)对前列腺癌(PCa)和良性前列腺增生(BPH)的诊断和鉴别诊断价值。方法使用ROCHE2010电化学发光免疫分析仪检测经临床确诊的42例PCa和88例BPH患者和52例健康者血清TPSA、FPSA含量并计算F/T。结果PCa组和BPH组与52例健康者的TPSA、FPSA及F/T相比差异有统计学意义(P<0.05),但有16例PCa和41例BPH患者位于诊断灰区(TPSA4～10 ng/mL),此时PCa组和BPH组患者的TPSA、FPSA值差异无统计学意义(P>0.05),但F/T差异有统计学意义(P<0.05)。结论对于TPSA值在诊断灰区内的良、恶性增生性疾病患者,F/T因其较高的敏感性和特异性更有助于PCa与BPH的鉴别诊断。
Objective To study the clinical value of total prostate spectific antigen（TPSA）,free prostate spe cific antigen（FPSA）,and the ratio of free to total prostate specific antigen（F/T） in differential diagnosis between prostate cancer（PCa） and benign prostate hyperplasia（BPH）. Methods With method of electrochemiluminoimmunoassay（ECL） ,TPSA and FPSA were measured in 42 cases of PCa and 88 cases of BPH and in 52 cases of heahby person group,and F/Tis ealculaled. Results In all patients,TPSA,FPSA and F/T were all significantly differenl（P〈 0.05）,but in diagnostic grey area（TPSA between 4 and 10 ng/mL） .there was no difference in TPSA between PCa group and BPH group（P〉0.05）. But F/T was significantly different in the two groups（P〈0.05）. Conclusion Serum TPSA is a marker for diagnosis of proslatic carcinoma,when TPSA level between 4 ng/mL and 10 ng/mL ,F/T ratio is of significanl value to differentiate PCa from BPH patients.
出处
《检验医学与临床》
CAS
2010年第1期13-14,共2页
Laboratory Medicine and Clinic
关键词
前列腺特异抗原
前列腺肿瘤
前列腺增生
电化学
发光测定法
鉴别诊断
prostate spcctific antigen
prostatic neoplasms
prostatic hyperplasia
electrochemistry
luminescent measurement
diagnosis, differential
