摘要
小分子热休克蛋白(small heat shock proteins,sHSPs)是热休克蛋白的亚单位,在各种应激状态下,它在组织中迅速表达增强,参与对组织的保护和损伤作用。sHSPs的研究已经受到国内外学者的广泛关注,认为其在作为分子伴侣、协同免疫、抑制凋亡、抗原提呈以及甾体激素受体功能等方面具有重要作用。充分认识sHSPs在眼部疾病中的功能及其作用机制,能进一步了解眼部疾病的发病机制,为疾病的治疗研究提供新的分子生物学依据。
Small heat shock proteins （sHSPs）, sHSPs are the subunit of heat shock protein（HSP）, which will express increased rapidly with a variety of stress state and take part in the protection and injury of organization. The research of sHSPs has attracted extensive attention from scholars at home and abroad. sHSPs play an important role in chaperone, collaborative immunization, inhibiting apoptosis, antigen-presenting and steroid hormone receptor. To fully recognize the mechanism of sHSPs in eye diseases can help understand the pathogenesis of eye diseases further and provide a new basis of molecular biology for the treatment of eye diseases.
出处
《国际眼科杂志》
CAS
2010年第1期108-110,共3页
International Eye Science
