摘要
糖原合酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)是调控糖原代谢的主要激酶.它可以使多种底物蛋白磷酸化,参与调节细胞增殖、细胞分化和细胞凋亡.最近研究表明,GSK-3β与帕金森病发生密切相关.在帕金森病研究模型中,GSK-3β活性增高,诱导多巴胺能神经元凋亡;而GSK-3β活性被抑制时,tau蛋白磷酸化减少,α共核蛋白表达降低,神经元得到保护.因此,GSK-3β可能成为帕金森病治疗的新靶点.
Glycogen synthase kinase-3β（GSK-3β） was initially identified as an enzyme involved in glycogen metabolism.GSK-3β phosphorylates a variety of substrates of different biological activities to regulate cellular functions,such as proliferation,differentiation and apoptosis.In the research model of the Parkinson＇s disease,the increase of GSK-3β activity was recently found to induce neuron apoptosis.On the other hand,when the GSK-3β activity was inhibited,both the tau protein phosphorylation and α-synuclein expression were reduced,then led to neural protection.Therefore,GSK-3β may become a new target for the treatment of Parkinson＇s disease.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2009年第12期1096-1101,共6页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金(No.3086085)
云南省应用基础研究项目(No.2007C177M)
云南省中青年学术技术带头人后备人才基金资助项目(No.2006YP01-07)~~
