摘要
目的:综述国内外有关MG29蛋白的研究进展及其与骨骼肌衰老的密切关系。资料来源:应用计算机检索中文CNKI数据库、读秀学术搜索和超星数字图书,检索关键词为MG29,骨骼肌衰老等;英文数据库为ElsevierSD和SpringerLink,检索关键词为MG29,aging skeletal muscle,sarcopenia等;此外还手工查阅多部相关专著。资料选择:纳入标准:①有关MG29蛋白的位置、结构与功能。②有关MG29蛋白与骨骼肌衰老。③有关MG29蛋白与运动。④同领域内近期发表的针对性强、影响因子大的相关文章。排除标准:重复研究文章或是Meta分析类文章。结局评价指标:MG29蛋白与骨骼肌衰老有密切关系。结果:国内外许多专家学者近年来从组织学、生物化学和分子生物学等方面对骨骼肌衰老进行了深入的研究。目前普遍认为钙是调控骨骼肌兴奋收缩偶联的核心元素,其动态平衡,即钙稳态的变化和骨骼肌衰老密切相关。MG29蛋白是最新发现的一种位于横管膜上调控钙机制的类突触素族蛋白。研究发现,衰老大鼠骨骼肌内的MG29蛋白减少了大约50%,有人将青年大鼠的MG29蛋白基因敲除,MG29蛋白缺陷的青年大鼠也出现了类似衰老大鼠的特征,如肌力下降、易疲劳、肌浆网碎裂、横管系统肿胀、钙火花的动态活性发生变化以及隔离的钙池等,这说明MG29蛋白与骨骼肌衰老紧密相关。结论:MG29蛋白与骨骼肌衰老密切相关,怎样通过改善MG29蛋白水平来延缓骨骼肌衰老将是后续研究的重点。
OBJECTIVE： To review research advances of Mitsugumin-29 （MG29） protein and its relationship with skeletal muscle aging. DATA SOURCES： A computer-based online search of CNKI （http：//www.chkd.cnki.net）, Duxiu （http：//edu.duxiu.com） and SSReader （http：//edu.sslibrary.com） with key words of MG29 and skeletal muscle aging in Chinese; Elsevier SD （http：//www.sciencedirect.com） and Springer Link （http：/Ispringer.metapress.comlhomelmain.mpx） with key words of MG29, aging skeletal muscle, sarcopenia. In addition, related articles were manually searched. DATA SELECTION： Inclusion criteria： location, structure and function of MG29; MG29 and skeletal muscle aging; MG29 and exercise; related articles aimed to the content with large impact factor. Exclusion criteria： repetitive studies or Meta analysis. MAIN OUTCOME MEASURES： MG29 has close relationship with skeletal muscle aging. RESULTS： In recent years, extensive researches have been conducted to discover the mechanisms underlying skeletal muscle aging by investigators home and abroad from histology, biochemistry and molecular biology. It is universally accepted that the changes in the cellular homeostatic capacity for Ca^2＋ is a core factor in regulating excitation contraction coupling, and it dynamic balance is the major cause of skeletal muscle aging. MG29, which is located in the membrane of transverse tubule, is a protein that is newly found to modulate Ca2＋ signal resembling the synaptophysins. Studies have shown that the level of MG29 reduced 50% in old skeletal muscle. Similar phenotypes to aging skeletal muscles have been observed in adolescent muscle null for MG29 which is involved in muscle weakness, increased susceptibility to muscle fatigue, fragmented sarcoplasmic reticulum networks, swollen transverse tubule system, altered calcium sparks, segregated Ca^2＋ reserve and so on. These suggest that MG29 and aging skeletal muscle are closely related. CONCLUSION： It has been confirmed that MG29 is highly correl
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第50期9950-9953,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
河北省自然科学基金资助项目(C2008000177)~~
