摘要
学术背景:骨骼肌Ca2+释放通道是骨骼肌内质网Ca2+释放与摄取的主要结构,与骨骼肌兴奋-收缩耦联密切相关,直接影响着骨骼肌的运动功能,尤其是骨骼肌的收缩速度与力量。目前,研究运动时骨骼骨钙释放通道的结构与功能的变化对于正确认识运动对骨骼肌的生物学作用,提高骨骼肌的收缩速度与力量具有重要的意义,也是某些相关疾病的运动康复与治疗的研究热点之一。目的:总结骨骼肌钙释放通道的特性及其运动时功能变化的研究进展。检索策略:由该论文的研究人员检索PubMed数据库2000-01/2007-06的相关文献,检索词"RYR1,exercise",限定文章语言种类为English。同时检索中国期刊全文数据库、万方数据库2000-01/2007-04期间的相关文章,检索词"骨骼肌钙释放通道;运动",限定文章语言种类为中文。共检索到42篇文献,对资料进行初审,纳入标准:①与骨骼肌钙释放通道运动时结构与功能的变化密切相关。②同一领域选择近期发表或在权威杂志上发表的文章。排除标准:重复性研究。文献评价:文献的来源主要是骨骼肌Ca2+释放通道在不同运动方式方面的随机对照试验。所选用的30篇文献中,6篇为综述,24篇为临床或基础实验研究。资料综合:①骨骼肌钙释放通道是调节骨骼肌细胞内Ca2+浓度的重要蛋白之一,直接参与了骨骼肌的兴奋收缩耦联过程。②有许多调节因素,如一些内源性蛋白(FK结合蛋白、钙调素、钙结合蛋白)和一些离子(Ca2+、Mg2+),通过不同的作用位点与骨骼肌钙释放通道结合,调控骨骼肌钙释放通道的结构与功能。③研究表明,骨骼肌在运动训练后通过二氢吡啶受体和骨骼肌钙释放通道这二种受体蛋白的表达水平提高而增强了肌肉的速度与力量能力;不同运动方式对骨骼肌钙释放通道的影响具有不同的特点。④关于骨骼肌钙释放通道方面的研究虽已取得较大�
BACKGROUND： Ca2＋ release channel or Ryanodine receptor 1 gene （RYRI） in skeletal muscles, the primal structure of Ca2＋ releasing and up-taking in skeletal muscle sarcoplasmic reticulum, is closely related to the process of the excitation-construction coupling of skeletal muscle, and could influence the motor function of skeletal muscle, especially the contraction speed and strength of skeletal muscle, Now it is important to study the structure and function changes of RYR1 after exercise for understanding the biological effectiveness of exercise on skeletal muscle and improving its contraction speed and strength, and it is the study hot spot on exercise rehabilitation of relevant diseases. OBJECTIVE： To summarize the study progress in the characteristics of RYRI and the function changes of RYRI in exercise, RETRIEVAL STRATEGY： A computer-based online search of PubMed database was undertaken for the related English literatures dated from January 2001 to June 2007 with the keywords of ＂RYRI, exercise＂. At the same time, we searched Chinese Periodical Full-text Database and Wanfang Database for the related articles published from January 2000 to April 2007 with the same keywords in Chinese. Totally 42 articles were collected, and after the first trail, only articles that （1）were closely related to the structure and function changes of RYR1 after exercise, and （2）published in recently or in the authoritative journals in the same domain were selected. Repetitive studies were excluded. LITERATURE EVALUATION： The source of these literatures is the randomized controlled trials mainly about RYR1 under different modes of exercise. Of the 30 selected literatures, 6 were review articles, and the others were clinical or basic empirical studies. DATA SYNTHESIS： （1）RYR1 is one of the important proteins regulating intracellular Ca2＋ concentration in skeletal muscle, and directly participates in the excitation contraction coupling of skeletal muscle. （2）There are many regulative factors, suc
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第2期339-343,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
