摘要
目的观察奥沙利铂联合希罗达治疗老年晚期胃癌的近期疗效及毒性反应。方法奥沙利铂130mg/m2,静脉滴注3h以上,第1天;希罗达2000mg/(m2·d),分2次口服,第1～14天。两药联合治疗晚期胃癌患者37例,21d为1个周期,至少连用2个周期。结果无完全缓解病例,部分缓解11例,有效率为29.73%;治疗后Karnofsky评分提高者19例(51.35%);主要毒性反应为外周感觉神经异常、骨髓抑制,患者均可以耐受。结论奥沙利铂联合希罗达方案治疗晚期胃癌疗效较好,毒副反应可以耐受,值得深入研究。
Objective To observe the clinical effect and toxicity of oxaliplatin combined with Xeloda in the treatment of 37 older patients with advanced gastric cancer. Methods All patients were treated with oxaliplatin（130 mg/m^2 by intravenous drip for 3 h on 1 d） combined with oral Xeloda （2000 mg/（m^2· d）, twice daily from 1 d to 14 d）. The regimen was repeated every 21 d for at least 2 consecutive cycles. Results The total response rate was 29.73% （11/37）, in which 0 got CR and 11 PR. Karnofsky score was increased in 19 cases（51.35% ）. The major toxic effects were peripheral neuritis and myelosuppression. Conclusion Oxaliplatin combined with Xeloda regimen is effective in the treatment of older patients with advanced gastric cancer, and its toxicity is tolerable, which needs further study in clinical practices.
出处
《中国药业》
CAS
2010年第1期41-42,共2页
China Pharmaceuticals
关键词
奥沙利铂
希罗达
联合化疗
晚期胃癌
oxaliplatin
Xeloda
combined chemotherapy
advanced older gastric cancer
