摘要
目的:探讨了急性白血病患者化疗前后血清Hcy、IGF-Ⅱ和TSGF水平的变化及临床意义。方法:应用免疫法、放免法和生化法对32例急性白血病患者进行了血清Hcy、IGF-Ⅱ和TSGF检测,并与35名正常健康人做比较。结果:急性白血病患者在化疗前血清Hcy、IGF-Ⅱ和TSGF水平非常显著地高于正常人组(P<0.01),化疗后6个月未复发的26例中明显下降接近正常人组,而复发的6例,其数值又回升到化疗前水平(P<0.05)。结论:检测白血病患者血清Hcy、IGF-Ⅱ和TSGF水平的变化可作为诊断和疗效观察的参考指标。
Objective To detect the changes of serum Hcy,IGF-Ⅱ and TSGF levels after chemotherapy in patients with acute leukemia.Methods Serum Hcy（with immune chemistry）,IGF-Ⅱ（with RIA）,TSGF（with biochemistry） levels were determined in 32 patients with acute leukemia both before and after chemotherapy as well as in 35 controls.Results Before chemotherapy,serum Hcy,IGF-Ⅱ and TSGF levels in the patients were significantly higher than those in the controls（P〈0.01）.Six months after chemotherapy the levels in 26 patients without recurrence dropped markedly and approached those in controls.However in the 6 patients with recurrence,the levels,after an early decrease,increased again,approaching those before ehemotherapy.Conclusion Serum levels of Hcy,IGF-Ⅱ and TSGF might be useful for outcome prediction after chemotherapy in patients with acute leukemia.
出处
《放射免疫学杂志》
CAS
2009年第6期569-570,共2页
Journal of Radioimmanology
关键词
急性白血病
同型半胱氨酸
胰岛素样生长因子-Ⅱ
肿瘤相关物质
acute leukemia
homocysteine（Hcy）
insulin-like growth factor-Ⅱ（IGF-Ⅱ）
tumor specific growth factor（TSGF）
