摘要
目的:探讨同型半胱氨酸(Hcy)、叶酸在酒精性肝病(ALD)患者诊断中的应用。方法:收治酒精性肝病患者213例,按病变程度分4组,轻型酒精性肝病62例,酒精性脂肪肝60例,酒精性肝炎54例,酒精性肝硬化37例,选取同期60例健康人群为对照组,比较各组血清标本中Hcy、叶酸水平。结果:治疗前轻型酒精性肝病组、酒精性脂肪肝组、酒精性肝炎组、酒精性肝硬化组血清Hcy、叶酸平均水平高于对照组(P<0.05);治疗后各组患者血清Hcy、叶酸水平均显著低于治疗前(P<0.05);酒精性肝硬化组治疗后血清Hcy、叶酸平均水平均显著高于对照组(P<0.05)。结论:ALD患者血清Hcy、叶酸水平的变化可反映肝功能损害程度,对疾病的诊断、治疗和预后判定具有一定的指导意义。
Objective:To discuss homocysteine and folic acid used in the diagnosis of alcoholic liver disease.Methods:213 patients with alcoholic liver disease were selected.According to the degree of lesions,4 cases of mild alcoholic liver disease,60 cases of alcoholic fatty liver,54 cases of alcoholic hepatitis,37 cases of alcoholic cirrhosis,and 60 cases of healthy group were selected as the control group. Hcy and folic acid levels in serum samples of all groups were compared.Results:Before treatment of mild alcoholic liver disease group,alcoholic fatty liver group,alcoholic hepatitis group and alcoholic cirrhosis group of serum Hcy,folate concentrations were higher than the control group(P<0.05);after treatment,the levels of serum Hcy and folate levels were significantly lower before the treatment(P<0.05);alcohol hepatocirrhosis group after treatment,the serum Hcy,folate concentrations were significantly higher than those of the control group(P<0.05).Conclusion:ALD patients of serum Hcy,folate levels may reflect changes in the degree of liver dysfunction.It has some significance in the diagnosis of disease,treatment and prognosis.
出处
《中国社区医师》
2015年第27期119-119,121,共2页
Chinese Community Doctors
