摘要
以金属钠与乙醇作用生成的乙醇钠为催化剂合成了香豆素-3-羧酸乙酯,再经皂化、酸解环合合成香豆素-3-羧酸。考察了各反应条件对香豆素-3-羧酸收率的影响。确定了最佳工艺条件为:n(水杨醛)∶n(丙二酸二乙酯)=1∶1.25,金属钠用量0.25 g、无水乙醇20 mL(均对4.0 g水杨醛),反应时间120 min,香豆素-3-羧酸的收率达到90%以上。
The synthesis of coumarin-3-carboxylic acid by saponification and aeidolysis cyclization of coumarin-3-carboxylic acid ethyl ester which was catalyzed by sodium ethoxide was studied. The effects of reaction condition were investigated. The optimum reaction conditions were obtained as follows： molar ratio of diethyl malonate to salicylaldehyde is 1.0 ： 1.25;the dosage of catalyst is 0. 25 g; the amount of absolute ethanol is 20 mI.;the reaction time is 120 min. Its yield achieves higher than 90%.
出处
《化工科技》
CAS
2009年第6期30-32,共3页
Science & Technology in Chemical Industry
