摘要
原发性肝细胞癌是世界上最常见的恶性肿瘤之一,慢性HBV感染是导致肝细胞癌的主要病因。HBV诱发肝细胞癌的确切机制仍不十分清楚。目前在HBV相关肝细胞癌病人血清和肝癌组织中发现了许多HBV X基因突变体,一些与肝细胞癌发生发展密切相关。本文主要就HBV X基因突变与肝细胞癌研究进展进行综述。
Hepatocellular carcinoma （HCC） is one of the most common malignant tumors worldwide. Epidemiological studies have convincingly shown that HCC is closely associated with chronic HBV infection. Although it is known that HCC develops many years after HBV infection, the exact molecular mechanisms of HBV in HCC have not yet been well understood. Studies repoit that the HBV X（HBx） gene containing substantial but different mutations are found in many HBV-infected HCC patients, part of them play crucial roles in the development of HCC. This review summarizes the current study of the HBx gene mutation and HCC.
出处
《胃肠病学和肝病学杂志》
CAS
2009年第12期1151-1153,共3页
Chinese Journal of Gastroenterology and Hepatology
基金
广东省医学科研基金项目(NO.A2008645)
深圳市科技计划项目(NO.200802144)
关键词
乙型肝炎病毒X基因
突变
肝细胞癌
Hepatitis B virus X gene
Mutation
Hepatocellular carcinoma
