摘要
慢性乙肝病毒(HBV)感染是原发性肝癌(HCC)发生发展的一个主要的危险因素。乙型肝炎病毒X蛋白(HBx)与HCC的形成密切相关,其反式激活功能被认为是HBV与HCC关联的主要因素。HBx的自然突变普遍存在于肝癌患者中,HBx突变在HCC中可能起关键作用。
Chronic infection by hepatitis B virus （HBV） is the leading cause of hepatocellular carcinoma （HCC）. The viral transactivator HBV X （HBx） gene is human closely associated with the molecular pathogenesis of HBV-related HCC, and transactivating function of HBx is considered to be a major cause involved in the development of the HBV-related HCC. Natural muhations of HBx protein are common feature in tumor tissue from the HBV-related HCC case. The mutantion of HBx gene may play a critical role in the pathogenesis of HBV-related HCC.
出处
《国际病理科学与临床杂志》
CAS
2006年第4期305-308,共4页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(30070344
30070839)
关键词
HBX
突变
肝细胞癌
hepatitis B virus X protein
mutation
hepatic cellular cancer
