摘要
目的评价肝动脉化疗栓塞（ＴＡＥ）结合Ｂ超引导下注射无水乙醇（ＰＥＩ）、３２Ｐ玻璃微球（３２ＰＧＭＳ）治疗原发性肝癌的临床价值。方法８３例中、晚期肝癌分为２组，４３例综合应用ＴＡＥ＋ＰＥＩ＋３２ＰＧＭＳ治疗，４０例单纯应用ＴＡＥ治疗。结果综合治疗组手术切除１４例（３３％），有９例肿瘤组织完全坏死，５例有残存的肿瘤细胞，单纯ＴＡＥ组手术切除４例（１０％），肿块及周边有肿瘤细胞，血清ＡＦＰ下降率及肿块缩小率两组比较有显著性差异（Ｐ＜０．０１），１、２、３年生存率综合治疗组分别为８４％，７２％，６７％，而ＴＡＥ组分别为５３％，１０％，０％。结论ＴＡＥ＋ＰＥＩ＋３２ＰＧＭＳ的综合应用，是提高中、晚期原发性肝癌患者存活率的有效方法。
Purpose To evaluate the clinical efficacy of transcatheter arterial chemoembolization(TAE) combined with percutaneous ethanol injection (PEI) and 32 P glass microspheres ( 32 P GMS) injection in the treatment of primary hepatocellular carcinoma (HCC). Methods 83 cases of moderate and advanced stages of HCC were divided into two groups, 43 cases were treated with TAE and followed subsequently by PEI and 32 P GMS. 40 cases were treated with TAE alone. Results 14(33%) cases were resected from the combination therapy group. In 9 cases, the lesions were completely necrotic. In 5 cases, partial viable tumor cells were found. 4(10%) cases were resected from the group with TAE alone, viable tumor cells were present in both the tumor mass and around the tumor. In the combination therapy group, the ratios of decrease in serum AFP level and reduction of tumor size were significantly greater than those in the TAE group ( P <0.01). In the combination therapy group, the 1, 2 and 3 year survival rates were 84%, 72% and 67%, respectively; as compared with the corresponding rates of 53%,10%,0% in the TAE group. Conclusion The combination of TAE with PEI and 32 P GMS in the treatment of HCC was an efficient method of increasing the survival rate.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
1998年第10期667-669,共3页
Chinese Journal of Radiology
关键词
肝肿瘤
药物疗法
栓塞疗法
介入放射学
Carcinoma
hepatocellular
Emboization
therapeutic
Radiology
interventional
